Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

This is a forthright and refreshing book. It aims to bring the clarifying power of analytic philosophy to the luxuriant variety in one part of Meinong's ontology. Parson's title is meant to be read literally: it is not propositions, numbers, universals or sets, but only particular objects whose nonexistence concerns him. Parsons gives two reasons for believing that there are nonexistent objects. First, we match objects against the sets of their properties. When every existing object has been listed, we carry (...) on making sets of properties. These additional sets correlate with nonexistent objects, e.g., the golden mountain. Second, there are the many occasions when we use names or definite descriptions to characterize truly such nonexistent objects as Pegasus and Sherlock Holmes. There is, says Parsons, no satisfactory reason for rephrasing these sentences when we refuse to paraphrase sentences of the same form having existing objects as their referents. (shrink)

Measuring event-related potentials (ERPs) has been fundamental to our understanding of how language is encoded in the brain. One particular ERP response, the N400 response, has been especially influential as an index of lexical and semantic processing. However, there remains a lack of consensus on the interpretation of this component. Resolving this issue has important consequences for neural models of language comprehension. Here we show that evidence bearing on where the N400 response is generated provides key insights into what it (...) reflects. A neuroanatomical model of semantic processing is used as a guide to interpret the pattern of activated regions in functional MRI, magnetoencephalography and intracranial recordings that are associated with contextual semantic manipulations that lead to N400 effects. (shrink)

Editors and commentators ancient and modern have not responded very well to the challenge of the two riddles which round off the contest between Damoetas and Menalcas at the end of Eclogue 3 . The first is generally regarded as impossibly difficult; the second as impossibly easy. Critics take refuge in quoting Servius' despairing statement: sciendum aenigmata haec sicuti pleraque carere aperta solutione. Yet it is most unlikely that Virgil would introduce insoluble or meaningless riddles into the Bucolica. If there (...) is no solution the lines become pointless, even tasteless; and these are not epithets to be applied lightly to Virgil's poetry. (shrink)

"It's a jungle out there. And in here, too. Through this jungle prowl all the demons of dirt and disorder. Though they must win eventually, the way to delay their victory is to keep everything in its proper place, and that means noticing any detail that doesn't fit." "Welcome to the world of former San Francisco police detective Adrian Monk, intellectual athlete and behavioral cripple, master of crime-solving and slave to his own terrors. Mr. Monk and Philosophy examines that world (...) through the lens of philosophy, bags all the evidence, and identifies DNA samples of Aristotle, Aquinas, Nietzsche, and Wittgenstein." --Book Jacket. (shrink)

Inside What Would Plato Do?, you'll find the basics of philosophy, written in an easy, digestible way we can all understand, along with questions to help you apply these important theories to your own life. So, after you've learned about a philosophical concept, you'll then be challenged to test yourself and see how the results can impact your daily life. For instance, after learning about Kant's theory of morality and the importance of intention you're challenged with questions like: Can good (...) people do bad things? Was there a time when you intended to do something helpful that ended up being hurtful? Does that make you a good person (because you intended to do good) or a bad person (because the results were bad)? What Would Plato Do? will not only help you better understand some of the greatest thinkers ever but will also help you think of the world around you in a whole new way! (shrink)

The editors of the new fragment of Gallus draw attention to line 6, ‘fecerunt carmina Musae’. They say ‘“fecerunt” is unusual in such a context, and to a Roman reader would inevitably suggest ; the Muses of Gallus provided craftsmanship as well as inspiration’. It is possible to be more precise: cf. Euphorion fr. 118 Powell.

Virtually the entire country, or in any event the socially active part of it, has at present but one aspiration—to "build capitalism" as rapidly as possible. An old ideological-psychological complex, not unique to our country—the notion of a horrible past , a difficult transitional period, and an earthly paradise to come after it, this time a capitalist paradise—is being resurrected in a new and "inverted" form. It seems to me that even the figure 500 in the 500-day program is no (...) accident but is reminiscent of the five-year plans. (shrink)

I welcome Mr Kennedy's general approach, but query whether the concept of consumerism is so closely applicable to medical care as he maintains. However, in particular aspects, especially the handling of complaints, his criticisms echo those made by the Patients Association. Finally, I detect some ground for hope in the more enlightened attitude creeping in to the eduction of the medical student.

Although neglected in the annals of political theory, the struggle between decentralized government and monarchy in the Hebrew scriptures parallels the tensions inherent in classic works of Western political theory from Plato to the American founders. The biblical authors provided lessons beyond the religious sphere, addressing the shared duties of religion and state in developing human virtue, the proper relationships between God, government and the people, and the best forms of government to achieve these objectives. This essay analyses the debate (...) over kingship in ancient Israel as presented in the biblical narratives, demonstrating that the Israelites’ story is important not only as a religious text, but as political theory, and that the questions asked in these texts have retained their relevance. (shrink)